About Me

Hi! I am MD and fourth year Ph.D. student at Medical University of Lodz, Poland.

I am doing my Ph.D. at Department of Biostatistics and Translational Medicine and I am broadly interested in using statistics, bioinformatics and mathematical modeling to uncover the connections between DNA damaging agents in cancer and adaptive immunity. I am also interested in statistical design of clinical trials.

My research is focused around radiation oncology, biostatistics and the impact of cytotoxic agents on the interaction of the cancer and host immune system. I am resident in Hematology at the Department of Hematology, Transplantology and Internal Medicine in Copernicus Memorial Hospital in Łódź, where my clinical focus is around acute leukemias, bone marrow transplantation and cellular therapies.

Links

• Google Scholar
• ResearchGate

Selected Papers

1. Pastorczak A, Urbanska Z, Styka B, Miarka-Walczyk K, Sedek L, Wypyszczak K, Wakulinska A, Nowicka Z, Szczepański T, Stańczak M, Fendler W, Kowalczyk J, Młynarski W, Lejman M. Genetic hallmarks and clinical implications of chromothripsis in childhood T-cell acute lymphoblastic leukemia.Leukemia. 2024 Nov;38(11):2344-2354. doi: 10.1038/s41375-024-02370-z

2. Sun Y, Patterson-Fortin J, Han S, Li Z, Nowicka Z, Hirohashi Y, Kilgas S, Yi JK, Spektor A, Fendler W, Konstantinopoulos PA, Chowdhury D. 53BP1 loss elicits cGAS-STING-dependent antitumor immunity in ovarian and pancreatic cancer. Nat Commun. 2024 Aug 6;15(1):6676. doi: 10.1038/s41467-024-50999-2

3. Nowicka Z, Kuna K, Łaszczych M, Łazar-Poniatowska M, Sobocki BK, Stawiski K, Dąbrowski M, Bruski K, Zięba A, Pajdziński M, Staniewska E, Miszczyk M, Paganetti H, Fendler W, Tomasik B. Dose-volume metric-based prediction of radiotherapy-induced lymphocyte loss in patients with non-small-cell lung cancer treated with modern radiotherapy techniques. Phys Imaging Radiat Oncol. 2024 May 27;30:100593. doi: 10.1016/j.phro.2024.100593

4. Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study. Nowicka Z, Tomasik B, Kozono D, Stawiski K, Johnson T, Haas-Kogan D, Ussowicz M, Chowdhury D, Fendler W. Radiother Oncol. 2023 Aug;185:109731. doi: 10.1016/j.radonc.2023.109731

5. Elias K, Smyczynska U, Stawiski K, Nowicka Z, Webber J, Kaplan J, Landen C, Lubinski J, Mukhopadhyay A, Chakraborty D, Connolly DC, Symecko H, Domchek SM, Garber JE, Konstantinopoulos P, Fendler W, Chowdhury D. Identification of BRCA1/2 mutation female carriers using circulating microRNA profiles. Nat Commun. 2023 Jun 8;14(1):3350. doi: 10.1038/s41467-023-38925-4.

6.Widmer CA, Klebic I, Domanitskaya N, Decollogny M, Howald D, Siffert M, Essers P, Nowicka Z, Stokar-Regenscheit N, van de Ven M, de Korte-Grimmerink R, Galván JA, Pritchard CEJ, Huijbers IJ, Fendler W, Vens C, Rottenberg S. Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy. Cancer Res Commun. 2022 Oct 26;2(10):1266-1281. doi: 10.1158/2767-9764.CRC-22-0208

7. Francica P, Mutlu M, Blomen VA, Oliveira C, Nowicka Z, Trenner A, Gerhards NM, Bouwman P, Stickel E, Hekkelman ML, Lingg L, Klebic I, van de Ven M, de Korte-Grimmerink R, Howald D, Jonkers J, Sartori AA, Fendler W, Chapman JR, Brummelkamp T, Rottenberg S. Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining. Cell Rep. 2020 Aug 25;32(8):108068. doi: 10.1016/j.celrep.2020.108068.

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